computational biology

3 items

RESEARCHDEV.to AI·4/19/2026

ECOSYNAPSE Volume II — Expansion Architecture Living Garden Intelligence: Ten Plants, Infinite Environments, One Evolving System

This whitepaper, EcoSynapse Volume II, details the biological, mathematical, and computational specifications of a "Living Garden Intelligence" system, expanding on its foundational architecture from Volume I. It focuses on ten specific plant agents, outlining their selection criteria, sourcing, and detailed biological profiles to function within multi-climate zones as one evolving system.

AI architecture bio-inspired AI computational biology sustainable AI

RESEARCHarXiv CS.LG·29d ago

Conditional generation of antibody sequences with classifier-guided germline-absorbing discrete diffusion

This research introduces a novel approach for conditional generation of antibody sequences, addressing limitations in current protein language models by better modeling somatic variation and enabling flexible classifier-guided generation. It proposes discrete diffusion fine-tuning and germline absorbing diffusion for improved antibody design.

Antibody Design Diffusion Models computational biology protein language models

RESEARCHarXiv CS.LG·26d ago

scShapeBench: Discovering geometry from high dimensional scRNAseq data

scShapeBench is a tool designed to discover geometry from high-dimensional single-cell RNA sequencing data, which is crucial for extracting biological information. It aims to automate shape detection, addressing the current reliance on manual visual inspection by bioinformaticians to select appropriate analysis pipelines.

single-cell RNAseq computational biology machine learning data analysis